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KMID : 0616120230540010009
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 1 p.9 ~ p.15
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Neuroprotective Activity of Cynaroside Isolated from Lysimachia christinae
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Ryu Ga-Hee
Ma Choong-Je
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Abstract
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In the previous study, we reported that cynaroside isolated from Lysimachia christinae methanolic extract had potent neuroprotective activities in neuronal cell death injured by excessive glutamate. In this study, we tried to confirm the neuroprotective activities of cynaroside in glutamate injured HT22 cells and establish mechanisms of neuroprotective action of cynaroside. We employed HT22 cells damaged by glutamate-induced cell death as a bioassay system. Cynaroside decreased reactive oxygen species increased by excessive glutamate treatment in HT22 cells. Also, Ca2+ concentration was decreased by cynaroside treatment. Cynaroside restored mitochondrial membrane potential to normal condition. It also increased not only glutathione reductase but also peroxidase to the control level. And it increased amount of glutathione, an endogenous antioxidant. These results suggested that cynaroside isolated from L. christinae showed potent neuroprotective activity through the anti-oxidative pathway.
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KEYWORD
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Lysimachia christinae, Cynaroside, Neuroprotection, Antioxidant, Alzheimer’s disease
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